Daily ambient temperatures and temperatures within the Zeepot were recorded every 3 h. Materials and Methods: Nobivac ® Rabies vaccine was stored under either cold-chain conditions or within the Zeepot for 2 months. We carried out a randomised controlled non-inferiority trial to compare serological responses in dogs following vaccination with doses stored under cold chain conditions with those stored within a locally made Passive Cooling Device (“Zeepot”) under fluctuating temperature conditions. Whether the vaccine would remain efficacious following storage under more natural, fluctuating temperature conditions remains unknown. A study from 2015 demonstrated that the potency of the Nobivac ® Rabies vaccine was not impacted following experimental storage at 30☌ for 3 months. Background: Thermostable vaccines greatly improved the reach and impact of large-scale programmes to eliminate infectious diseases such as smallpox, polio, and rinderpest.
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